Background levels of neomorphic 2-hydroxyglutarate facilitate proliferation of primary fibroblasts /
Each cell types or tissues contain certain “physiological” levels of R-2-hydroxyglutarate (2HG), as well as enzymes for its synthesis and degradation. 2HG accumulates in certain tumors, possessing heterozygous point mutations of isocitrate dehydrogenases IDH1 (cytosolic) or IDH2 (mitochondrial) and...
Hlavní autor: |
Dvořák, A.
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Autor )
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Další autoři: |
Zelenka, Jaroslav, 1980-
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Autor )
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Typ dokumentu: | Článek |
Jazyk: |
angličtina |
ISSN: | 0862-8408 |
Zdroj: | Physiological research: Vol. 66, is. 2 (2017), s. 293-304. |
Předmět: | |
Externí odkaz: |
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