Background levels of neomorphic 2-hydroxyglutarate facilitate proliferation of primary fibroblasts /
Each cell types or tissues contain certain “physiological” levels of R-2-hydroxyglutarate (2HG), as well as enzymes for its synthesis and degradation. 2HG accumulates in certain tumors, possessing heterozygous point mutations of isocitrate dehydrogenases IDH1 (cytosolic) or IDH2 (mitochondrial) and...
| Hlavní autor: |
Dvořák, A.
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Autor )
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| Další autoři: |
Zelenka, Jaroslav, 1980-
(
Autor )
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| Typ dokumentu: | Článek |
| Jazyk: |
angličtina |
| ISSN: | 0862-8408 |
| Zdroj: | Physiological research: Vol. 66, is. 2 (2017), s. 293-304. |
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