Rapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway

Autor: Pinaki Misra, Ravindra Kodali, Saketh Chemuru, Karunakar Kar, Ronald Wetzel
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms12419
Popis: The elucidation of amyloid nucleation mechanisms remains challenging as early oligomeric intermediates are transient and difficult to distinguish. Here the authors use Aβ- polyglutamine hybrid peptides designed to slow and limit amyloid maturation to provide insights into the structures of Aβ self-assembly intermediates.
Databáze: Directory of Open Access Journals