Signet ring cell carcinoma of the gastrointestinal tract: National trends on treatment effects and prognostic outcomes

Autor: Jan Franko, Viet H. Le, May C. Tee, Mayin Lin, Jessica Sedinkin, Shankar Raman, Daniela Frankova
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Cancer Treatment and Research Communications, Vol 29, Iss , Pp 100475- (2021)
Druh dokumentu: article
ISSN: 2468-2942
DOI: 10.1016/j.ctarc.2021.100475
Popis: Background: Signet ring cell carcinoma (SRCC) is a distinct malignancy occurring across the tubular gastrointestinal tract (tGIT). We comprehensively examined the outcomes of patients diagnosed with SRCC across tGIT. Methods: SRCC and not-otherwise-specified adenocarcinoma (NOS) patients reported to the National Cancer Database from 2004 to 2015 were included. Baseline characteristics, outcomes and site-specific adjusted hazard ratios (aHR) derived from Cox models of SRCC patients were compared to those of NOS patients. Overall survival (OS) was primary endpoint. Results: A total of 41,686 SRCC (4.6%) and 871,373 NOS patients (95.4%) were included. SRCC patients were younger (63.1 ± 14.7 vs. 67.0 ± 13.4 y, p
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