Liver governs adipose remodelling via extracellular vesicles in response to lipid overload

Autor: Yue Zhao, Meng-Fei Zhao, Shan Jiang, Jing Wu, Jia Liu, Xian-Wen Yuan, Di Shen, Jing-Zi Zhang, Nan Zhou, Jian He, Lei Fang, Xi-Tai Sun, Bin Xue, Chao-Jun Li
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-14450-6
Popis: Extracellular vesicles (EVs) containing miRNAs or proteins can coordinate metabolic responses between tissues. Here the authors demonstrate that during lipid overload, the liver secretes miRNA-containing EVs through a Ggpps-Rab27 dependent mechanism, which controls adipose tissue lipid storage capacity.
Databáze: Directory of Open Access Journals