Dealing with rectum motion during radiotherapy: How can we anticipate it?

Autor: Julien Pierrard, Sofie Heylen, Ad Vandermeulen, Geneviève Van Ooteghem
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Technical Innovations & Patient Support in Radiation Oncology, Vol 32, Iss , Pp 100277- (2024)
Druh dokumentu: article
ISSN: 2405-6324
DOI: 10.1016/j.tipsro.2024.100277
Popis: Introduction: Intra- and inter-fraction rectum motion is important for pelvic radiotherapy (RT). This study assesses how RT session duration, the presence or the absence of an intra-rectal tumour, and the distance from the anorectal junction (ARJd) impact rectal motion. Materials and methods: Analyses used cone-beam computed tomographies (CBCTs) from RT patients treated for rectal and prostate cancer. Three structures were evaluated: (1) the entire rectum in patients without a rectal tumour (RectumProstate); (2) the non-invaded portion (RectumRectum) and (3) the tumour-invaded portion (RectumTumour) in rectal cancer patients.Intrafraction motion was assessed using the Hausdorff distance 95% and the Mean distance-to-agreement between structures delineated on the first CBCT and the 2 subsequent CBCTs within a same RT session. Interfraction motion was quantified by comparing structures delineated on the planning-CT and the first CBCT of each session.Linear mixed model evaluated rectum motion in relation to time, tumour presence, and ARJd, respectively. Results: We included 10 patients with and 10 without rectal cancer, collecting 385 CBCTs. A significant correlation (p RectumRectum and RectumTumour, p
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