An Convenient Synthesis of Ricinine and Its Analogues

Autor: Didier Villemin, Florian Faucher, Nathalie Bar, Zahira Kibou, Noureddine Choukchou-Braham
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Chemistry Proceedings, Vol 8, Iss 1, p 74 (2021)
Druh dokumentu: article
ISSN: 2673-4583
DOI: 10.3390/ecsoc-25-11676
Popis: Ricinine is an alkaloid of Ricinus communis that displays numerous biological properties. Ricinine (4-methoxy-1-methyl-2-oxo-dihydropyridine-3-carbonitrile)) and new N-analogues of Ricinine were obtained by the reaction of ethyl α-ethoxyethylidenecyanoacetate with various amines. Earlier, ethyl α-ethoxyethylidenecyanoacetate was easily prepared from ethyl cyanoacetate. Biologically, amines such as tryptamine and histamine were used in order to introduce a second pharmacophore on the target molecule.
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