Secondary Acute Myeloid Leukemia in a Chronic Myeloid Leukemia Patient in Deep Molecular Response—An Unusual Case Report

Autor: Goranthala Bharathi Devi, Perumal Kalaiyarasi Jayachandran, Jhansi Rani Arumugam, Karthik Bommannan, Shirley Sundersingh
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: South Asian Journal of Cancer, Vol 11, Iss 02, Pp 175-177 (2022)
Druh dokumentu: article
ISSN: 2278-330X
2278-4306
DOI: 10.1055/s-0041-1739178
Popis: Abstract Perumal Kalaiyarasi Jayachandran Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder that develops from the stem cell compartment. The classical translocation (BCR-ABL1) is present in approximately 95% of CML patients. Through disease progression, clonal evolution with additional chromosomal abnormalities (ACAs) start appearing. Although relatively rare, chromosomal abnormalities can exist or develop in the Philadelphia (Ph)-negative clones, which may lead to the evolution of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). We hereby present a case of AML which emerged from a Ph-negative clone in a patient with a history of CML who was in deep molecular response. The possible mechanisms of ACAs have been discussed.
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