Secondary Acute Myeloid Leukemia in a Chronic Myeloid Leukemia Patient in Deep Molecular Response—An Unusual Case Report

Autor:	Goranthala Bharathi Devi, Perumal Kalaiyarasi Jayachandran, Jhansi Rani Arumugam, Karthik Bommannan, Shirley Sundersingh
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	aml in cml secondary aml additional chromosomal abnormalities in ph-negative clone clonal evolution secondary clone Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	South Asian Journal of Cancer, Vol 11, Iss 02, Pp 175-177 (2022)
Druh dokumentu:	article
ISSN:	2278-330X 2278-4306
DOI:	10.1055/s-0041-1739178
Popis:	Abstract Perumal Kalaiyarasi Jayachandran Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder that develops from the stem cell compartment. The classical translocation (BCR-ABL1) is present in approximately 95% of CML patients. Through disease progression, clonal evolution with additional chromosomal abnormalities (ACAs) start appearing. Although relatively rare, chromosomal abnormalities can exist or develop in the Philadelphia (Ph)-negative clones, which may lead to the evolution of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). We hereby present a case of AML which emerged from a Ph-negative clone in a patient with a history of CML who was in deep molecular response. The possible mechanisms of ACAs have been discussed.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/4ac163f7d5324e3b80d363295d774ab8 Zobrazit plný text záznamu View record in DOAJ