Blue-grey hyperpigmentation in acne after vandetanib therapy and doxycycline use: A case report

Autor: Jonah W Perlmutter, Rachel C Cogan, Marni C Wiseman
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: SAGE Open Medical Case Reports, Vol 10 (2022)
Druh dokumentu: article
ISSN: 2050-313X
2050313X
DOI: 10.1177/2050313X221086316
Popis: Vandetanib is an oral tyrosine kinase inhibitor with cutaneous adverse effects that include the development of acne. We present a patient who underwent vandetanib therapy for stage IV medullary thyroid cancer in conjunction with the use of doxycycline for acne that developed. After vandetanib use, blue-grey pigmentation developed in the acne on his face, chest, back, and arms, which darkened after the use of doxycycline. We review the literature to report that this blue-grey hyperpigmentation was likely vandetanib-induced but may have been the result of both drugs being used in combination.
Databáze: Directory of Open Access Journals