Synthesis and In Vitro Antimycobacterial and Antibacterial Activity of 8-OMe Ciprofloxacin-Hydrozone/Azole Hybrids

Autor: Zhi Xu, Shu Zhang, Lian-Shun Feng, Xiao-Ning Li, Guo-Cheng Huang, Yun Chai, Zao-Sheng Lv, Hui-Yuan Guo, Ming-Liang Liu
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Molecules, Vol 22, Iss 7, p 1171 (2017)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/molecules22071171
Popis: A series of novel 8-OMe ciprofloxacin (CPFX)-hydrazone/azole hybrids were designed, synthesized, and evaluated for their in vitro biological activities. Our results reveal that all of the hydrozone-containing hybrids (except for 7) show potency against Mycobacterium tuberculosis (MTB) H37Rv (minimum inhibitory concentration (MIC):
Databáze: Directory of Open Access Journals