Mitochondrial DNA Copy Number in Peripheral Blood Is Reduced in Type 2 Diabetes Patients with Polyneuropathy and Associated with a

Autor:	Andrea, Latini, Paola, Borgiani, Giada, De Benedittis, Cinzia, D'Amato, Carla, Greco, Davide, Lauro, Giuseppe, Novelli, Vincenza, Spallone, Cinzia, Ciccacci
Rok vydání:	2020
Předmět:	Male DNA Copy Number Variations Genotype Middle Aged DNA Mitochondrial Polymorphism Single Nucleotide Mitochondria MicroRNAs Oxidative Stress Polyneuropathies Diabetes Mellitus Type 2 Diabetic Neuropathies Humans Female Genetic Predisposition to Disease Alleles Genetic Association Studies
Zdroj:	DNA and cell biology. 39(8)
ISSN:	1557-7430
Popis:	Our aim was to evaluate in a cohort of 125 Italian patients with type 2 diabetes (T2D), who underwent neurological evaluation, the possible differences in the number of mitochondrial DNA copies (mtDNA) comparing positive and negative patients for cardiovascular autonomic neuropathy (CAN) or diabetic peripheral neuropathy (DPN) and comparing them with healthy controls. We also investigated a possible correlation of the number of mtDNA copies with the polymorphism rs3746444 of the
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::e3d5cae3ca01056d3435a67ef244eef3 https://pubmed.ncbi.nlm.nih.gov/32311290 Zobrazit plný text záznamu