[AMP deaminase activity in hyperoxia and the effect of AMP on animal sensitivity to oxygen under pressure]

Autor:	I A, Goroshinskaia, Z G, Bronovitskaia
Rok vydání:	1991
Předmět:	Male Oxygen Atmosphere Exposure Chambers Cytoplasm Seizures Animals Brain Female Drug Tolerance Adenosine Monophosphate AMP Deaminase Mitochondria Rats
Zdroj:	Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova. 77(2)
ISSN:	0015-329X
Popis:	Under the effects of 0.7 MPa of oxygen leading to a convulsive state, AMP-deaminase activity increased significantly in the rat brain mitochondrial fraction with only a tendency to increase in cytoplasmic fraction. Stimulated effects of the enzyme allosteric activator ATP is more obvious in intact animals than in hyperoxic ones. Pretreatment with AMP before hyperoxygenation exerts a protective effect preventing the alteration of monoamine oxydase catalytic properties, stabilizing membrane structure and improving the general state of the animals.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c3ed79a4e6b37663635b94ff26e042a5 https://pubmed.ncbi.nlm.nih.gov/1652522 Zobrazit plný text záznamu