Bradykinin antagonists do not require a D-aromatic amino acid residue at position 7

Autor:	R J, Vavrek, L, Gera, J M, Stewart
Rok vydání:	1992
Předmět:	Structure-Activity Relationship Ileum Guinea Pigs Molecular Sequence Data Uterus Animals Blood Pressure Female Amino Acid Sequence In Vitro Techniques Bradykinin Rats
Zdroj:	Agents and actions. Supplements. 38
ISSN:	0379-0363
Popis:	More than 200 new analogs of bradykinin have been synthesized and assayed. Analogs containing a D-aliphatic amino acid residue at position 7 and an L-aliphatic residue at position 8 are very potent antagonists of BK action on classical systems. Thus the "conventional wisdom" that a D-aromatic amino acid residue is required at sequence position 7 of BK antagonists must be modified.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::62b2f01ffe418af8fd5d3284c966f992 https://pubmed.ncbi.nlm.nih.gov/1466298 Zobrazit plný text záznamu