Wegener's granulomatosis and alpha1-antitrypsin-deficiency emphysema: proteinase-related diseases

Autor: V T, Barnett, M, Sekosan, A, Khurshid
Rok vydání: 1999
Předmět:
Zdroj: Chest. 116(1)
ISSN: 0012-3692
Popis: Wegener's granulomatosis (WG) and alpha1-antitrypsin (alpha1-AT)-deficiency emphysema are both uncommon disorders. A relationship may exist between these diseases involving the proteinase and antiproteinase balance in the lung. A case is presented of WG and alpha1-AT-deficiency emphysema occurring in the same patient. Previous studies concerning the correlation between abnormal alpha1-AT alleles and WG are discussed. Potential mechanisms for the relationship and recommendations for screening are given.
Databáze: OpenAIRE