Serum Uric Acid and Risk for Acute Kidney Injury Following Contrast

Autor: Mehmet, Kanbay, Yalcin, Solak, Baris, Afsar, Ionut, Nistor, Gamze, Aslan, Ozlem Hilal, Çağlayan, Asli, Aykanat, Mihaela-Dora, Donciu, Miguel A, Lanaspa, Ahsan A, Ejaz, Richard J, Johnson, Adrian, Covic
Rok vydání: 2016
Předmět:
Zdroj: Angiology. 68(2)
ISSN: 1940-1574
Popis: Contrast-induced acute kidney injury (CI-AKI) is a common cause of hospital-acquired acute kidney injury (AKI). We evaluated the evidence that uric acid (UA) plays a pathogenic role in CI-AKI. Ten studies were eligible for inclusion for meta-analysis. Hyperuricemia predicted risk for cases with AKI in prospective cohort studies. Higher levels of serum UA (SUA), as defined by the authors, were associated with a 2-fold increased risk to develop AKI (pooled odds ratio 2.03; 95% confidence interval [CI] 1.48-2.78). Significant heterogeneity was found in cohort studies ( P = .001, I
Databáze: OpenAIRE