Orthoester functionalized
Autor: | Alen, Sevšek, Javier, Sastre Toraño, Linda, Quarles van Ufford, Ed E, Moret, Roland J, Pieters, Nathaniel I, Martin |
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Rok vydání: | 2017 |
Předmět: | |
Zdroj: | MedChemComm. 8(11) |
ISSN: | 2040-2503 |
Popis: | Alkylated guanidino derivatives of 1,5-dideoxy-1,5-imino-d-xylitol bearing an orthoester moiety were prepared using a concise synthetic protocol. Inhibition assays with a panel of glycosidases revealed that one of the compounds prepared displays potent inhibition against human β-glucocerebrosidase (GBA) at pH 7.0 with IC |
Databáze: | OpenAIRE |
Externí odkaz: |
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