| Autor: |
Alen, Sevšek, Javier, Sastre Toraño, Linda, Quarles van Ufford, Ed E, Moret, Roland J, Pieters, Nathaniel I, Martin |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
MedChemComm. 8(11) |
| ISSN: |
2040-2503 |
| Popis: |
Alkylated guanidino derivatives of 1,5-dideoxy-1,5-imino-d-xylitol bearing an orthoester moiety were prepared using a concise synthetic protocol. Inhibition assays with a panel of glycosidases revealed that one of the compounds prepared displays potent inhibition against human β-glucocerebrosidase (GBA) at pH 7.0 with IC |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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