Generic Solving of One-compartment Toxicokinetic Models
| Autor: | Christelle Lopes, Sandrine Charles, Aude Ratier |
|---|---|
| Přispěvatelé: | Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), ANR-17-EURE-0018,H2O'LYON,School of Integrated Watershed Sciences(2017) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
ODE
Computer science physiologically based toxicokinetic TK 0211 other engineering and technologies metabolism and excretion Inference 02 engineering and technology EFSA 010501 environmental sciences ordinary differential equation 030226 pharmacology & pharmacy 01 natural sciences 0302 clinical medicine [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST] Bioaccumulation metrics. Abbreviations: ADME Active substances [STAT.AP]Statistics [stat]/Applications [stat.AP] Toxicokinetic models Authorization [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] toxicokinetic ERA Ordinary differential equation [SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology [STAT.ME]Statistics [stat]/Methodology [stat.ME] Ordinary differential equations Physiologically based pharmacokinetic modelling PBPK PBTK environmental risk assessment Set (abstract data type) 03 medical and health sciences [MATH.MATH-GM]Mathematics [math]/General Mathematics [math.GM] [SDV.EE.ECO]Life Sciences [q-bio]/Ecology environment/Ecosystems distribution Applied mathematics European food safety authority Compartment (pharmacokinetics) physiologically based pharmacokinetic 0105 earth and related environmental sciences Environmental risk assessment 021110 strategic defence & security studies Living organisms [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation [SDE.ES]Environmental Sciences/Environmental and Society Biochemical engineering [SDE.BE]Environmental Sciences/Biodiversity and Ecology absorption [SDV.EE.IEO]Life Sciences [q-bio]/Ecology environment/Symbiosis |
| Zdroj: | Journal of Exploratory Research in Pharmacology Journal of Exploratory Research in Pharmacology, 2021, ⟨10.14218/JERP.2021.00024⟩ Journal of Exploratory Research in Pharmacology, Xia & He Publishing, 2021, ⟨10.14218/JERP.2021.00024⟩ |
| ISSN: | 2572-5505 |
| DOI: | 10.14218/JERP.2021.00024⟩ |
| Popis: | This paper gives the full analytical solution of the generic set of ordinary differential equations that define one-compartment toxicokinetic models. These models describe uptake and elimination processes taking place within living organisms when exposed to chemical substances. The models solved in this paper consider living organisms as a unique compartment, into which a parent compound enters via several possible exposure routes and from which it is eliminated as well as its potential metabolites. Benefiting from generic solutions of one-compartment toxicokinetic models is particularly useful when fitting them to experimental data, facilitating the writing of the inference algorithms leading to parameter estimates. Additionally, these models are of crucial interest in environmental risk assessment for the calculation of bioaccumulation metrics as required by regulators in support of decision making when they evaluate dossiers for marketing authorisation of active substances.Abstract FigureGraphical abstract |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|