Diagnostic value of alpha-fetoprotein combined with neutrophil-to-lymphocyte ratio for hepatocellular carcinoma

Autor: Jian Hu, Wei Zhang, Ruilin Han, Cunling Yan, Xiaoqin Wang, Yijie Zheng, Yongfeng Yang, Li Ma, Nianyue Wang
Rok vydání: 2017
Předmět:
Adult
Male
medicine.medical_specialty
Carcinoma
Hepatocellular
Neutrophils
Hepatocellular carcinoma
Neutrophil-granulocyte ratio
Gastroenterology
Diagnosis
Differential
03 medical and health sciences
Liver disease
Leukocyte Count
0302 clinical medicine
Internal medicine
medicine
Humans
In patient
Aspartate Aminotransferases
Lymphocytes
Neutrophil to lymphocyte ratio
lcsh:RC799-869
Retrospective Studies
Receiver operating characteristic
business.industry
Liver Diseases
fungi
Liver Neoplasms
Alanine Transaminase
General Medicine
Hepatology
Middle Aged
medicine.disease
digestive system diseases
030220 oncology & carcinogenesis
Alpha-fetoprotein
030211 gastroenterology & hepatology
lcsh:Diseases of the digestive system. Gastroenterology
Female
alpha-Fetoproteins
business
Area under the roc curve
Biomarkers
Research Article
Zdroj: BMC Gastroenterology
BMC Gastroenterology, Vol 18, Iss 1, Pp 1-7 (2018)
ISSN: 1471-230X
Popis: Background To investigate the diagnostic performance of alpha-fetoprotein (AFP) and neutrophil-to-lymphocyte ratio (NLR) as well as their combinations with other markers. Methods Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), AFP and levels as well as the numbers of neutrophils and lymphocytes of all enrolled patients were collected. The NLR was calculated by dividing the number of neutrophils by the number of lymphocytes. Receiver operating characteristic (ROC) curve analysis was conducted to determine the ability of each marker and combination of markers to distinguish HCC and liver disease patients. Results In total, 545 patients were included in this study. The area under the ROC curve (AUC) values for AFP, ALT, AST, and NLR were 0.775 (0.738–0.810), 0.504 (0.461–0.547), 0.660 (0.618–0.699), and 0.738 (0.699–0.774) with optimal cut-off values of 24.6 ng/mL, 111 IU/mL, 27 IU/mL, and 2.979, respectively. Of the four biomarkers, AFP and NLR showed comparable specificity (0.881 and 0.858) and sensitivity (0.561 and 0.539). The combination of AFP and NLR showed the highest AUC (0.769) with a significantly higher sensitivity (0.767) and a lower specificity (0.773) compared to AFP or NLR alone, and it had the highest sum of sensitivity and specificity (1.54) among all combinations. In patients with AFP
Databáze: OpenAIRE
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