Diagnostic value of alpha-fetoprotein combined with neutrophil-to-lymphocyte ratio for hepatocellular carcinoma
Autor: | Jian Hu, Wei Zhang, Ruilin Han, Cunling Yan, Xiaoqin Wang, Yijie Zheng, Yongfeng Yang, Li Ma, Nianyue Wang |
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Rok vydání: | 2017 |
Předmět: |
Adult
Male medicine.medical_specialty Carcinoma Hepatocellular Neutrophils Hepatocellular carcinoma Neutrophil-granulocyte ratio Gastroenterology Diagnosis Differential 03 medical and health sciences Liver disease Leukocyte Count 0302 clinical medicine Internal medicine medicine Humans In patient Aspartate Aminotransferases Lymphocytes Neutrophil to lymphocyte ratio lcsh:RC799-869 Retrospective Studies Receiver operating characteristic business.industry Liver Diseases fungi Liver Neoplasms Alanine Transaminase General Medicine Hepatology Middle Aged medicine.disease digestive system diseases 030220 oncology & carcinogenesis Alpha-fetoprotein 030211 gastroenterology & hepatology lcsh:Diseases of the digestive system. Gastroenterology Female alpha-Fetoproteins business Area under the roc curve Biomarkers Research Article |
Zdroj: | BMC Gastroenterology BMC Gastroenterology, Vol 18, Iss 1, Pp 1-7 (2018) |
ISSN: | 1471-230X |
Popis: | Background To investigate the diagnostic performance of alpha-fetoprotein (AFP) and neutrophil-to-lymphocyte ratio (NLR) as well as their combinations with other markers. Methods Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), AFP and levels as well as the numbers of neutrophils and lymphocytes of all enrolled patients were collected. The NLR was calculated by dividing the number of neutrophils by the number of lymphocytes. Receiver operating characteristic (ROC) curve analysis was conducted to determine the ability of each marker and combination of markers to distinguish HCC and liver disease patients. Results In total, 545 patients were included in this study. The area under the ROC curve (AUC) values for AFP, ALT, AST, and NLR were 0.775 (0.738–0.810), 0.504 (0.461–0.547), 0.660 (0.618–0.699), and 0.738 (0.699–0.774) with optimal cut-off values of 24.6 ng/mL, 111 IU/mL, 27 IU/mL, and 2.979, respectively. Of the four biomarkers, AFP and NLR showed comparable specificity (0.881 and 0.858) and sensitivity (0.561 and 0.539). The combination of AFP and NLR showed the highest AUC (0.769) with a significantly higher sensitivity (0.767) and a lower specificity (0.773) compared to AFP or NLR alone, and it had the highest sum of sensitivity and specificity (1.54) among all combinations. In patients with AFP |
Databáze: | OpenAIRE |
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