Phosphoinositide-dependent enrichment of actin monomers in dendritic spines regulates synapse development and plasticity

Autor: James Q. Zheng, Kenneth R. Myers, Wenliang Lei, Denis Tsygankov, Yanfang Rui, Siarhei Hladyshau
Rok vydání: 2016
Předmět:
Zdroj: The Journal of Cell Biology
ISSN: 1540-8140
2016-1204
Popis: Katalin Schlett previews the study by Lei et al., which reveals that dendritic spines contain local pools of G-actin that are dynamically regulated in response to synaptic activity by profilin and PIP3.
Synaptic activity reshapes the morphology of dendritic spines via regulating F-actin arborization. In this issue, Lei et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201612042) reports a novel, G-actin–dependent regulation of actin polymerization within spine heads. They show that actin monomer levels are elevated in spines upon activity, with G-actin immobilized by the local enrichment of phosphatidylinositol (3,4,5)-triphosphate (PIP3) within the spine plasma membrane.
Databáze: OpenAIRE
načítá se...