Phosphoinositide-dependent enrichment of actin monomers in dendritic spines regulates synapse development and plasticity
| Autor: | James Q. Zheng, Kenneth R. Myers, Wenliang Lei, Denis Tsygankov, Yanfang Rui, Siarhei Hladyshau |
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| Rok vydání: | 2016 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Dendritic spine Time Factors Dendritic Spines macromolecular substances Biology Transfection Hippocampus Second Messenger Systems Synaptic Transmission Tissue Culture Techniques 03 medical and health sciences Actin remodeling of neurons Profilins 0302 clinical medicine Phosphatidylinositol Phosphates Animals Spotlight Cytoskeleton Cells Cultured Neuronal Plasticity PTEN Phosphohydrolase Actin remodeling Excitatory Postsynaptic Potentials Cell Biology Actin cytoskeleton Actins Cell biology Dendritic filopodia Rats Actin Cytoskeleton 030104 developmental biology Profilin Microscopy Fluorescence Synaptic plasticity Synapses biology.protein Commentary RNA Interference 030217 neurology & neurosurgery |
| Zdroj: | The Journal of Cell Biology |
| ISSN: | 1540-8140 2016-1204 |
| Popis: | Katalin Schlett previews the study by Lei et al., which reveals that dendritic spines contain local pools of G-actin that are dynamically regulated in response to synaptic activity by profilin and PIP3. Synaptic activity reshapes the morphology of dendritic spines via regulating F-actin arborization. In this issue, Lei et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201612042) reports a novel, G-actin–dependent regulation of actin polymerization within spine heads. They show that actin monomer levels are elevated in spines upon activity, with G-actin immobilized by the local enrichment of phosphatidylinositol (3,4,5)-triphosphate (PIP3) within the spine plasma membrane. |
| Databáze: | OpenAIRE |
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