Specificity of the effects of steroids on bilirubin glucuronide transport by liver slice
| Autor: | B.P.F. Adlard, G.H. Lathe |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Male
medicine.medical_specialty Bilirubin Conjugated bilirubin Biophysics Pregnanediol Glucuronide Bilirubin glucuronide Glucuronates Liver slice In Vitro Techniques Androsterone Biochemistry chemistry.chemical_compound Internal medicine Etiocholanolone medicine Animals Molecular Biology Pregnanolone Chemistry Sulfates Biological Transport Pregnanes Rats Endocrinology Liver Steroids medicine.drug |
| Zdroj: | Biochimica et biophysica acta. 237(1) |
| ISSN: | 0006-3002 |
| Popis: | 1. 1. Steroids with 5α-configuration failed to inhibit the system even at 25 times the concentration previously used. 2. 2. Pregnanolone and aetiocholanolone glucuronides acted like pregnanediol glucuronide in producing a rise of conjugated bilirubin in the slices. 3. 3. Pregnanolone and aetiocholanolone sulphates were without effect. 4. 4. The effect of 5β-steroids on bile pigment secretion is specific for glucuronides, liver and the rat. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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