Post-dexamethasone serum copeptin corresponds to HPA axis responsiveness in human obesity

Autor: Klara Meyer, Matthias Blüher, Johannes Orthgiess, Florian Then Bergh, Jürgen Kratzsch, Muriel Stoppe, Julia Luthardt, Osama Sabri, Lukas Bechmann, Christian Schinke, Swen Hesse, Elisa Schmidt, Anke Bresch, Michael Rullmann
Rok vydání: 2016
Předmět:
Zdroj: Psychoneuroendocrinology. 78
ISSN: 1873-3360
Popis: Context Increased activities of the arginine-vasopressin (AVP) system and the hypothalamic-pituitary-adrenal (HPA) axis were shown to be associated with human obesity, but relationships between these systems in obesity remain unclear. Objectives To assess HPA axis responsiveness and its relation to serum concentrations of the AVP-surrogate copeptin in subjects with obesity (OB) in comparison to non-obesity controls (NOC). Methods In a cross-sectional monocentric study, thirty-nine OB (f/m 25/14; age 36.5 ± 10.0 years; body mass index, BMI, 41.5 ± 4.7 kg/m2) were compared to twenty-two NOC (f/m 12/10; age 35.3 ± 8.5 years; BMI 23.1 ± 2.4 kg/m2), matched for age and sex. All individuals underwent the combined dexamethasone/CRH test. Main outcome measures Plasma ACTH and cortisol curve indicators derived from the dex/CRH test (post-CRH concentrations 30 min after 100 μg CRH; maximum concentration, MAX; area-under-the-curve, AUC; ACTH/cortisol ratios). Copeptin was assessed in 1500 h samples of the dex/CRH test (after 1.5 mg of oral dexamethasone, prior to CRH administration). Results Copeptin serum concentrations were higher in OB (median [IQR]: OB 4.62 [2.60–5.88] vs. NOC 3.04 [2.52–4.29] pmol/l, P = 0.04). Correspondingly, OB showed higher post-CRH cortisol concentrations (OB: 51.5 [25.9–159.3] vs. NOC: 28.6 [20.0–41.6] nmol/l, P = 0.01) and a lower post-CRH ACTH/cortisol ratio (OB: 0.028 [0.016–0.053] vs. NOC: 0.048 [0.034–0.070] pmol/nmol, P
Databáze: OpenAIRE
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