Post-dexamethasone serum copeptin corresponds to HPA axis responsiveness in human obesity
| Autor: | Klara Meyer, Matthias Blüher, Johannes Orthgiess, Florian Then Bergh, Jürgen Kratzsch, Muriel Stoppe, Julia Luthardt, Osama Sabri, Lukas Bechmann, Christian Schinke, Swen Hesse, Elisa Schmidt, Anke Bresch, Michael Rullmann |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Hypothalamo-Hypophyseal System Hydrocortisone Endocrinology Diabetes and Metabolism Pituitary-Adrenal System 030209 endocrinology & metabolism Context (language use) Adrenocorticotropic hormone Neuroendocrinology Dexamethasone 03 medical and health sciences 0302 clinical medicine Endocrinology Copeptin Adrenocorticotropic Hormone Internal medicine medicine Humans Obesity Biological Psychiatry Endocrine and Autonomic Systems Glycopeptides Middle Aged medicine.disease Psychiatry and Mental health Cross-Sectional Studies Female Pituitary-Adrenal Function Tests Psychology Body mass index hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Psychoneuroendocrinology. 78 |
| ISSN: | 1873-3360 |
| Popis: | Context Increased activities of the arginine-vasopressin (AVP) system and the hypothalamic-pituitary-adrenal (HPA) axis were shown to be associated with human obesity, but relationships between these systems in obesity remain unclear. Objectives To assess HPA axis responsiveness and its relation to serum concentrations of the AVP-surrogate copeptin in subjects with obesity (OB) in comparison to non-obesity controls (NOC). Methods In a cross-sectional monocentric study, thirty-nine OB (f/m 25/14; age 36.5 ± 10.0 years; body mass index, BMI, 41.5 ± 4.7 kg/m2) were compared to twenty-two NOC (f/m 12/10; age 35.3 ± 8.5 years; BMI 23.1 ± 2.4 kg/m2), matched for age and sex. All individuals underwent the combined dexamethasone/CRH test. Main outcome measures Plasma ACTH and cortisol curve indicators derived from the dex/CRH test (post-CRH concentrations 30 min after 100 μg CRH; maximum concentration, MAX; area-under-the-curve, AUC; ACTH/cortisol ratios). Copeptin was assessed in 1500 h samples of the dex/CRH test (after 1.5 mg of oral dexamethasone, prior to CRH administration). Results Copeptin serum concentrations were higher in OB (median [IQR]: OB 4.62 [2.60–5.88] vs. NOC 3.04 [2.52–4.29] pmol/l, P = 0.04). Correspondingly, OB showed higher post-CRH cortisol concentrations (OB: 51.5 [25.9–159.3] vs. NOC: 28.6 [20.0–41.6] nmol/l, P = 0.01) and a lower post-CRH ACTH/cortisol ratio (OB: 0.028 [0.016–0.053] vs. NOC: 0.048 [0.034–0.070] pmol/nmol, P |
| Databáze: | OpenAIRE |
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