Putting the brakes on centromere drive in Mimulus
| Autor: | Thomas C. Nelson, Lila Fishman, Findley R. Finseth |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
Cancer Research Mimulus QH426-470 01 natural sciences Suppressor Genes Histones Homologous Chromosomes Chromosome Segregation Cell Cycle and Cell Division Genetics (clinical) Centromeres 0303 health sciences education.field_of_study Chromosome Biology Kinetochore Genomics Meiosis Histone Cell Processes Perspective Chromosome Structure and Function Quantitative Trait Loci Centromere Population Biology Research and Analysis Methods 010603 evolutionary biology Chromosomes Chromosomes Plant Evolution Molecular 03 medical and health sciences Gene Types Genetics Molecular Biology Techniques education Molecular Biology Ecology Evolution Behavior and Systematics 030304 developmental biology Polymorphism Genetic Gene Mapping Biology and Life Sciences Cell Biology DNA biology.organism_classification Meiotic drive Haplotypes Genetic Loci Evolutionary biology biology.protein Selective sweep |
| Zdroj: | PLoS Genetics, Vol 17, Iss 4, p e1009418 (2021) PLoS Genetics |
| ISSN: | 1553-7404 1553-7390 |
| Popis: | Centromeres are essential mediators of chromosomal segregation, but both centromeric DNA sequences and associated kinetochore proteins are paradoxically diverse across species. The selfish centromere model explains rapid evolution by both components via an arms-race scenario: centromeric DNA variants drive by distorting chromosomal transmission in female meiosis and attendant fitness costs select on interacting proteins to restore Mendelian inheritance. Although it is clear than centromeres can drive and that drive often carries costs, female meiotic drive has not been directly linked to selection on kinetochore proteins in any natural system. Here, we test the selfish model of centromere evolution in a yellow monkeyflower (Mimulus guttatus) population polymorphic for a costly driving centromere (D). We show that theDhaplotype is structurally and genetically distinct and swept to a high stable frequency within the past 1500 years. We use quantitative genetic mapping to demonstrate that context-dependence in the strength of drive (from near-100%Dtransmission in interspecific hybrids to near-Mendelian in within-population crosses) primarily reflects variable vulnerability of the non-driving competitor chromosomes, but also map an unlinked modifier of drive coincident with kinetochore protein Centromere-specific Histone 3 A (CenH3A). Finally, CenH3A exhibits a recent (Din ongoing adaptive evolution of this kinetochore protein. Together, our results demonstrate an active co-evolutionary arms race between DNA and protein components of the meiotic machinery inMimulus, with important consequences for individual fitness and molecular divergence. |
| Databáze: | OpenAIRE |
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