Putting the brakes on centromere drive in Mimulus

Autor: Thomas C. Nelson, Lila Fishman, Findley R. Finseth
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0106 biological sciences
Cancer Research
Mimulus
QH426-470
01 natural sciences
Suppressor Genes
Histones
Homologous Chromosomes
Chromosome Segregation
Cell Cycle and Cell Division
Genetics (clinical)
Centromeres
0303 health sciences
education.field_of_study
Chromosome Biology
Kinetochore
Genomics
Meiosis
Histone
Cell Processes
Perspective
Chromosome Structure and Function
Quantitative Trait Loci
Centromere
Population
Biology
Research and Analysis Methods
010603 evolutionary biology
Chromosomes
Chromosomes
Plant

Evolution
Molecular

03 medical and health sciences
Gene Types
Genetics
Molecular Biology Techniques
education
Molecular Biology
Ecology
Evolution
Behavior and Systematics

030304 developmental biology
Polymorphism
Genetic

Gene Mapping
Biology and Life Sciences
Cell Biology
DNA
biology.organism_classification
Meiotic drive
Haplotypes
Genetic Loci
Evolutionary biology
biology.protein
Selective sweep
Zdroj: PLoS Genetics, Vol 17, Iss 4, p e1009418 (2021)
PLoS Genetics
ISSN: 1553-7404
1553-7390
Popis: Centromeres are essential mediators of chromosomal segregation, but both centromeric DNA sequences and associated kinetochore proteins are paradoxically diverse across species. The selfish centromere model explains rapid evolution by both components via an arms-race scenario: centromeric DNA variants drive by distorting chromosomal transmission in female meiosis and attendant fitness costs select on interacting proteins to restore Mendelian inheritance. Although it is clear than centromeres can drive and that drive often carries costs, female meiotic drive has not been directly linked to selection on kinetochore proteins in any natural system. Here, we test the selfish model of centromere evolution in a yellow monkeyflower (Mimulus guttatus) population polymorphic for a costly driving centromere (D). We show that theDhaplotype is structurally and genetically distinct and swept to a high stable frequency within the past 1500 years. We use quantitative genetic mapping to demonstrate that context-dependence in the strength of drive (from near-100%Dtransmission in interspecific hybrids to near-Mendelian in within-population crosses) primarily reflects variable vulnerability of the non-driving competitor chromosomes, but also map an unlinked modifier of drive coincident with kinetochore protein Centromere-specific Histone 3 A (CenH3A). Finally, CenH3A exhibits a recent (Din ongoing adaptive evolution of this kinetochore protein. Together, our results demonstrate an active co-evolutionary arms race between DNA and protein components of the meiotic machinery inMimulus, with important consequences for individual fitness and molecular divergence.
Databáze: OpenAIRE
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