Hydroxycinnamoylmalated flavone C -glycosides from Lemna japonica
| Autor: | Tao Yang, Ni-Ni Wang, Jiao Mi, Guo-You Li, Dong-Mei Fang, Lin-Wei Wu, Hai Zhao, Huan-Huan Bai |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0106 biological sciences
Stereochemistry Flavonoid Biology Alkaline hydrolysis (body disposal) 01 natural sciences Flavones Antioxidants Araceae chemistry.chemical_compound Caffeic Acids Glucosides Cell Line Tumor Drug Discovery Caffeic acid Animals Humans Glycosides Tylenchoidea Apigenin Anthelmintics Pharmacology chemistry.chemical_classification Molecular Structure 010405 organic chemistry Glycoside General Medicine biology.organism_classification Antineoplastic Agents Phytogenic 0104 chemical sciences chemistry Luteolin 010606 plant biology & botany |
| Zdroj: | Fitoterapia. 124:211-216 |
| ISSN: | 0367-326X |
| DOI: | 10.1016/j.fitote.2017.11.010 |
| Popis: | Three previously undescribed flavone C-glycosides (1-3), along with seven known ones (4-10), were isolated and characterized from the smallest flowering aquatic plant, Lemna japonica. On the basis of spectroscopic analysis and alkaline hydrolysis, compounds 1-3 were identified to be luteolin 6-C-(2″-O-trans-caffeoyl-d-malate)-β-glucoside (1), apigenin 6-C-(2″-O-trans-caffeoyl-d-malate)-β-glucoside (2), and luteolin 6-C-(2″-O-trans-coumaroyl-d-malate)-β-glucoside (3). Compounds 1-3 are characteristic of a trans-coumaroyl-d-malate or trans-caffeoyl-d-malate linked to C-2″ of the glucose, which was reported for the first time. Compounds 1-3 exhibited weak cytotoxicity against HepG-2, SW-620, and A-549 cell lines, with IC50 values between 42.5 and 19.2μg/ml, and moderate antioxidant activity. Meanwhile compound 3 displayed moderate nematocidal activity with an EC50 value of 1.56mg/ml. |
| Databáze: | OpenAIRE |
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