Impact of diabetes mellitus on coagulation function before and after off-pump coronary artery bypass grafting
| Autor: | Yu Liu, Da-Wei Wang, Zhen-Ming Zhang, Ziying Chen, Yu-Lei Wei, Fei Yang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Aspirin medicine.diagnostic_test Abnormal bleeding business.industry medicine.medical_treatment medicine.disease Clopidogrel Thromboelastography medicine.anatomical_structure Diabetes mellitus Internal medicine Inclusion and exclusion criteria Cardiology medicine Original Article business medicine.drug Artery Off-pump coronary artery bypass |
| Zdroj: | Journal of Thoracic Disease. 11:5517-5526 |
| ISSN: | 2077-6624 2072-1439 |
| DOI: | 10.21037/jtd.2019.11.27 |
| Popis: | BACKGROUND: This study aims to explore the influence of off-pump coronary artery bypass grafting (OPCABG) on coagulation function and the effects of diabetes on coagulation function during OPCABG. METHODS: Patients who met the inclusion and exclusion criteria were divided into two groups: diabetes mellitus (DM) and non-diabetes mellitus (NDM) groups. Thromboelastography (TEG) was tested at the following time points: T0, five days after aspirin and clopidogrel therapy, and before OPCABG; T1, returning to care unit after OPCABG; T2, 5 days after aspirin and clopidogrel therapy, and after OPCABG. RESULTS: A total of 56 patients were involved. There were no deaths, or no early postoperative thrombotic events and abnormal bleeding after OPCABG. Intra-group comparison: Compared with T0, the R and K value decreased, while the α angle and MA value increased at T1 and T2, in both groups (P0.05). CONCLUSIONS: The coagulation function of patients was at a hypercoagulable state at the early stage after OPCABG. The coagulation function was affected by diabetes at the day of OPCABG. However, there was no statistical difference after 5 days of aspirin and clopidogrel therapy following OPCABG. |
| Databáze: | OpenAIRE |
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