The Effect of Resveratrol on Sphingosine-1 and Oxidative/ Nitrosative Stress in an Experimental Heart Ischemia Reperfusion Model

Autor: Avnioğlu, Seda, Güngör, Meltem, Kurutaş, Ergül, Öztürk, Ünal, Demirhan, İlter, Bakariş, Sevgi, Velioğlu, Halil Aziz, Çankaya, Şeyda, Yuluğ, Burak
Přispěvatelé: ALKÜ, Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
Rok vydání: 2022
Předmět:
Zdroj: Revista Romana de Medicina de Laborator. 30:9-18
ISSN: 2284-5623
DOI: 10.2478/rrlm-2021-0036
Popis: Objectives: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this study, we aimed to investigate the effects of resveratrol on the sphingosine-1-phosphate (S1P) and oxidative stress biomarkers in hearth ischemia-reperfusion (I/R). Materials and Methods: The biochemical and histopathological effects of RSV on cardiac ischemia-reperfusion injury were investigated through ELISA- and light microscope. Results: We observed statistically significant differences between the treatment group and the control group in terms of malondialdehyde (MDA) level, catalase (CAT) and superoxide dismutase (SOD) activities (p Conclusion: Resveratrol may play an important role in cardiac I/R injury through its anti-inflammatory and antioxidant effects which were biochemically and histopathologically confirmed in the present study.
Databáze: OpenAIRE