Admission macrophage migration inhibitory factor predicts long-term prognosis in patients with ST-elevation myocardial infarction
| Autor: | Qing-Bian Ma, Xiangning Deng, Xinyu Wang, Xiao-Jun Du, Wei Huai, Youyi Zhang, Xinye Xu, Haiyi Yu, Wei Gao, Anthony M. Dart, Gui-Hua Liu, Shaomin Chen |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty China Time Factors medicine.medical_treatment Infarction 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Patient Admission Percutaneous Coronary Intervention Risk Factors Internal medicine Cause of Death medicine Humans cardiovascular diseases Myocardial infarction Macrophage Migration-Inhibitory Factors Retrospective Studies Ejection fraction business.industry Health Policy Hazard ratio Percutaneous coronary intervention Middle Aged medicine.disease Prognosis Intramolecular Oxidoreductases Survival Rate 030104 developmental biology Conventional PCI Cardiology ST Elevation Myocardial Infarction Macrophage migration inhibitory factor Female Cardiology and Cardiovascular Medicine business Mace Biomarkers Follow-Up Studies |
| Zdroj: | European heart journal. Quality of careclinical outcomes. 4(3) |
| ISSN: | 2058-1742 |
| Popis: | Aims We previously showed in patients with ST-segment elevated myocardial infarction (STEMI) that admission levels of macrophage migration inhibitory factor (MIF) predict infarct size. We studied whether admission MIF alone or in combination with other biomarkers is useful for risk assessment of acute and chronic clinical outcomes in STEMI patients. Methods and results A total of 658 STEMI patients treated with primary percutaneous coronary intervention (PCI) were consecutively recruited. MIF level was determined at admission and echocardiography performed on day-3 and then 12 months post-MI. Patients were followed for a median period of 64 months. Major endpoints included ST-segment resolution, all-cause mortality, and major adverse cardiovascular events (MACE). High MIF level was associated with larger enzymatic infarct size, incomplete resolution of ST-segment elevation post-PCI, impaired left ventricular ejection fraction (LVEF), and poorer improvement of LVEF (all P |
| Databáze: | OpenAIRE |
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