Admission macrophage migration inhibitory factor predicts long-term prognosis in patients with ST-elevation myocardial infarction

Autor: Qing-Bian Ma, Xiangning Deng, Xinyu Wang, Xiao-Jun Du, Wei Huai, Youyi Zhang, Xinye Xu, Haiyi Yu, Wei Gao, Anthony M. Dart, Gui-Hua Liu, Shaomin Chen
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
medicine.medical_specialty
China
Time Factors
medicine.medical_treatment
Infarction
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Patient Admission
Percutaneous Coronary Intervention
Risk Factors
Internal medicine
Cause of Death
medicine
Humans
cardiovascular diseases
Myocardial infarction
Macrophage Migration-Inhibitory Factors
Retrospective Studies
Ejection fraction
business.industry
Health Policy
Hazard ratio
Percutaneous coronary intervention
Middle Aged
medicine.disease
Prognosis
Intramolecular Oxidoreductases
Survival Rate
030104 developmental biology
Conventional PCI
Cardiology
ST Elevation Myocardial Infarction
Macrophage migration inhibitory factor
Female
Cardiology and Cardiovascular Medicine
business
Mace
Biomarkers
Follow-Up Studies
Zdroj: European heart journal. Quality of careclinical outcomes. 4(3)
ISSN: 2058-1742
Popis: Aims We previously showed in patients with ST-segment elevated myocardial infarction (STEMI) that admission levels of macrophage migration inhibitory factor (MIF) predict infarct size. We studied whether admission MIF alone or in combination with other biomarkers is useful for risk assessment of acute and chronic clinical outcomes in STEMI patients. Methods and results A total of 658 STEMI patients treated with primary percutaneous coronary intervention (PCI) were consecutively recruited. MIF level was determined at admission and echocardiography performed on day-3 and then 12 months post-MI. Patients were followed for a median period of 64 months. Major endpoints included ST-segment resolution, all-cause mortality, and major adverse cardiovascular events (MACE). High MIF level was associated with larger enzymatic infarct size, incomplete resolution of ST-segment elevation post-PCI, impaired left ventricular ejection fraction (LVEF), and poorer improvement of LVEF (all P
Databáze: OpenAIRE
Externí odkaz: