Repetitive transcranial magnetic stimulation increases serum brain-derived neurotrophic factor and decreases interleukin-1β and tumor necrosis factor-α in elderly patients with refractory depression

Autor: Qing Tian, Bingqian Zhu, Xiang-xiang Zhao, Yan-peng Li, Zhongxin Zhao
Rok vydání: 2019
Předmět:
Male
Medicine (General)
medicine.medical_specialty
Clinical Research Reports
interleukin-1β
Repetitive transcranial magnetic stimulation
medicine.medical_treatment
Interleukin-1beta
refractory depression
behavioral disciplines and activities
Biochemistry
Depressive Disorder
Treatment-Resistant
03 medical and health sciences
R5-920
0302 clinical medicine
Refractory
Neurotrophic factors
Internal medicine
medicine
Humans
Tumor necrosis factor α
Depression (differential diagnoses)
Aged
Brain-derived neurotrophic factor
Tumor Necrosis Factor-alpha
business.industry
Brain-Derived Neurotrophic Factor
Biochemistry (medical)
Interleukin
Cell Biology
General Medicine
Middle Aged
Transcranial Magnetic Stimulation
elderly patient
030227 psychiatry
Transcranial magnetic stimulation
Endocrinology
nervous system
Female
Tumor necrosis factor alpha
tumor necrosis factor-α
business
030217 neurology & neurosurgery
Zdroj: Journal of International Medical Research, Vol 47 (2019)
The Journal of International Medical Research
ISSN: 1473-2300
0300-0605
DOI: 10.1177/0300060518817417
Popis: Objective To investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on serum levels of brain-derived neurotrophic factor (BDNF), interleukin (IL)-1β, and tumor necrosis factor (TNF)-α in elderly patients with refractory depression. Methods A total of 58 elderly patients diagnosed with refractory depression between January 2015 and December 2016 were divided randomly into two groups: 29 patients who received rTMS and 29 controls without rTMS. Thirty healthy individuals were also enrolled and all received rTMS. Serum levels of BDNF, IL-1β, and TNF-α were measured before the study (0 days), and at 48 hours and 1, 2, 3, and 4 weeks after the first TMS treatment. Results BDNF levels gradually increased with treatment duration in the rTMS group and were significantly higher compared with the control group. In contrast, IL-1β and TNF-α levels gradually decreased and were significantly lower than in the control group. None of the serum factors were affected by rTMS in the healthy individuals. BDNF levels were negatively correlated and IL-1β and TNF-α levels were positively correlated with Hamilton Depression Rating Scale-24 scores. Conclusion These results suggest that rTMS may increase BDNF and decrease IL-1β and TNF-α serum levels in elderly patients with refractory depression.
Databáze: OpenAIRE
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