Repetitive transcranial magnetic stimulation increases serum brain-derived neurotrophic factor and decreases interleukin-1β and tumor necrosis factor-α in elderly patients with refractory depression
| Autor: | Qing Tian, Bingqian Zhu, Xiang-xiang Zhao, Yan-peng Li, Zhongxin Zhao |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Medicine (General) medicine.medical_specialty Clinical Research Reports interleukin-1β Repetitive transcranial magnetic stimulation medicine.medical_treatment Interleukin-1beta refractory depression behavioral disciplines and activities Biochemistry Depressive Disorder Treatment-Resistant 03 medical and health sciences R5-920 0302 clinical medicine Refractory Neurotrophic factors Internal medicine medicine Humans Tumor necrosis factor α Depression (differential diagnoses) Aged Brain-derived neurotrophic factor Tumor Necrosis Factor-alpha business.industry Brain-Derived Neurotrophic Factor Biochemistry (medical) Interleukin Cell Biology General Medicine Middle Aged Transcranial Magnetic Stimulation elderly patient 030227 psychiatry Transcranial magnetic stimulation Endocrinology nervous system Female Tumor necrosis factor alpha tumor necrosis factor-α business 030217 neurology & neurosurgery |
| Zdroj: | Journal of International Medical Research, Vol 47 (2019) The Journal of International Medical Research |
| ISSN: | 1473-2300 0300-0605 |
| Popis: | Objective To investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on serum levels of brain-derived neurotrophic factor (BDNF), interleukin (IL)-1β, and tumor necrosis factor (TNF)-α in elderly patients with refractory depression. Methods A total of 58 elderly patients diagnosed with refractory depression between January 2015 and December 2016 were divided randomly into two groups: 29 patients who received rTMS and 29 controls without rTMS. Thirty healthy individuals were also enrolled and all received rTMS. Serum levels of BDNF, IL-1β, and TNF-α were measured before the study (0 days), and at 48 hours and 1, 2, 3, and 4 weeks after the first TMS treatment. Results BDNF levels gradually increased with treatment duration in the rTMS group and were significantly higher compared with the control group. In contrast, IL-1β and TNF-α levels gradually decreased and were significantly lower than in the control group. None of the serum factors were affected by rTMS in the healthy individuals. BDNF levels were negatively correlated and IL-1β and TNF-α levels were positively correlated with Hamilton Depression Rating Scale-24 scores. Conclusion These results suggest that rTMS may increase BDNF and decrease IL-1β and TNF-α serum levels in elderly patients with refractory depression. |
| Databáze: | OpenAIRE |
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