Knockdown of Pentraxin 3 suppresses tumorigenicity and metastasis of human cervical cancer cells

Autor: Hui-Ling Chiou, Yi-Hsien Hsieh, Chien-Hsing Lee, Chu-Liang Lin, Tsung-Ho Ying, Shun-Fa Yang, Jen-Pi Tsai, Chia-Hung Hung
Rok vydání: 2016
Předmět:
Zdroj: Scientific Reports
ISSN: 2045-2322
DOI: 10.1038/srep29385
Popis: Pentraxin 3 (PTX3) as an inflammatory molecule has been shown to be involved in immune response, inflammation, and cancer. However, the effects of PTX3 on the biological features of cervical cancer cells in vitro and in vivo have not been delineated. Immunohistochemical staining showed that increased PTX3 expression was significantly associated with tumor grade (P in vivo functional studies showed PTX3-knockdown in mice suppressed tumorigenicity and lung metastatic potential. Conversely, overexpression of PTX3 enhanced proliferation and invasion both in vitro and in vivo. Our results demonstrated that PTX3 contributes to tumorigenesis and metastasis of human cervical cancer cells. Further studies are warranted to demonstrate PTX3 as a novel therapeutic biomarker for human cervical cancer.
Databáze: OpenAIRE
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