Knockdown of Pentraxin 3 suppresses tumorigenicity and metastasis of human cervical cancer cells
| Autor: | Hui-Ling Chiou, Yi-Hsien Hsieh, Chien-Hsing Lee, Chu-Liang Lin, Tsung-Ho Ying, Shun-Fa Yang, Jen-Pi Tsai, Chia-Hung Hung |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine CA15-3 Pathology medicine.medical_specialty Lung Neoplasms Uterine Cervical Neoplasms Biology medicine.disease_cause Article Metastasis Small hairpin RNA Mice 03 medical and health sciences 0302 clinical medicine Cell Movement Cancer stem cell Cell Line Tumor medicine Animals Humans Cell Proliferation Multidisciplinary Cell growth Cancer Middle Aged Cell cycle medicine.disease Up-Regulation Gene Expression Regulation Neoplastic Serum Amyloid P-Component C-Reactive Protein 030104 developmental biology Gene Knockdown Techniques 030220 oncology & carcinogenesis Cancer research Female Neoplasm Grading Carcinogenesis Neoplasm Transplantation HeLa Cells |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep29385 |
| Popis: | Pentraxin 3 (PTX3) as an inflammatory molecule has been shown to be involved in immune response, inflammation, and cancer. However, the effects of PTX3 on the biological features of cervical cancer cells in vitro and in vivo have not been delineated. Immunohistochemical staining showed that increased PTX3 expression was significantly associated with tumor grade (P in vivo functional studies showed PTX3-knockdown in mice suppressed tumorigenicity and lung metastatic potential. Conversely, overexpression of PTX3 enhanced proliferation and invasion both in vitro and in vivo. Our results demonstrated that PTX3 contributes to tumorigenesis and metastasis of human cervical cancer cells. Further studies are warranted to demonstrate PTX3 as a novel therapeutic biomarker for human cervical cancer. |
| Databáze: | OpenAIRE |
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