Synthesis of Novel Pentacyclic Triterpenoid Derivatives that Induce Apoptosis in Cancer Cells through a ROS-dependent, Mitochondrial-Mediated Pathway
| Autor: | Boyang Cheng, Xindang Chu, Ruiwen Liu, Xinyuan Ma, Mengyang Wang, Jiayi Zhang, Pingxuan Jiao, Qianqian Gao, Wenxiao Ma, Yongmin Zhang, Chuanke Zhao, Demin Zhou, Sulong Xiao |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Molecular Pharmaceutics. 20:701-710 |
| ISSN: | 1543-8392 1543-8384 |
| DOI: | 10.1021/acs.molpharmaceut.2c00885 |
| Popis: | Betulinic acid (BA) and oleanolic acid (OA) are plant-derived conjugates found in various medicinal plants that have emerged as potential antitumor agents. Herein, a series of novel BA and OA derivatives were synthesized by conjugation with per |
| Databáze: | OpenAIRE |
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