Synthesis of Novel Pentacyclic Triterpenoid Derivatives that Induce Apoptosis in Cancer Cells through a ROS-dependent, Mitochondrial-Mediated Pathway

Autor:	Boyang Cheng, Xindang Chu, Ruiwen Liu, Xinyuan Ma, Mengyang Wang, Jiayi Zhang, Pingxuan Jiao, Qianqian Gao, Wenxiao Ma, Yongmin Zhang, Chuanke Zhao, Demin Zhou, Sulong Xiao
Rok vydání:	2022
Předmět:	Neoplasms Drug Discovery Humans Pharmaceutical Science Molecular Medicine Apoptosis Antineoplastic Agents HL-60 Cells Reactive Oxygen Species Pentacyclic Triterpenes Triterpenes
Zdroj:	Molecular Pharmaceutics. 20:701-710
ISSN:	1543-8392 1543-8384
DOI:	10.1021/acs.molpharmaceut.2c00885
Popis:	Betulinic acid (BA) and oleanolic acid (OA) are plant-derived conjugates found in various medicinal plants that have emerged as potential antitumor agents. Herein, a series of novel BA and OA derivatives were synthesized by conjugation with per
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac581b2f7ad61096056e6885dc4a5805 https://doi.org/10.1021/acs.molpharmaceut.2c00885 Zobrazit plný text záznamu