Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice

Autor: N E Lane, Christian Vaisse, Wei Yao, S. S. Ionova-Martin, Simon Y. Tang, Robert O. Ritchie, M. Shahnazari, Tamara Alliston, Joel W. Ager, J. M. Wade
Rok vydání: 2011
Předmět:
Glycation End Products
Advanced
Leptin
Blood Glucose
Male
Aging
Bone density
Endocrinology
Diabetes and Metabolism
Cortical bone
Inbred C57BL
Weight Gain
Mice
0302 clinical medicine
Bone Density
Medicine
2.1 Biological and endogenous factors
Scanning
Femur
Insulin-Like Growth Factor I
Pediatric
0303 health sciences
Microscopy
Diabetes
Anatomy
Biomechanical Phenomena
medicine.anatomical_structure
Body Composition
Public Health and Health Services
Original Article
medicine.symptom
medicine.medical_specialty
Fracture risk
Clinical Sciences
Biomedical Engineering
Glycation End Products
030209 endocrinology & metabolism
Diet
High-Fat
Metabolic and Endocrine
Electron
Bone and Bones
Diabetes Mellitus
Experimental
03 medical and health sciences
Experimental
Endocrinology & Metabolism
Diabetes mellitus
Internal medicine
Diabetes Mellitus
Glycosylation End Products
Animals
Tibia
Obesity
030304 developmental biology
Nutrition
business.industry
Fracture toughness
medicine.disease
Diet
Mice
Inbred C57BL
High-Fat
Endocrinology
Musculoskeletal
Microscopy
Electron
Scanning
Osteoporosis
Advanced
business
Weight gain
Osteoporotic Fractures
Zdroj: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol 22, iss 8
Ionova-Martin, SS; Wade, JM; Tang, S; Shahnazari, M; Ager, JW; Lane, NE; et al.(2011). Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice. Osteoporosis International, 22(8), 2283-2293. doi: 10.1007/s00198-010-1432-x. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/0gd109hq
Osteoporosis International
DOI: 10.1007/s00198-010-1432-x.
Popis: Summary: Diabetic obesity is associated with increased fracture risk in adults and adolescents. We find in both adolescent and adult mice dramatically inferior mechanical properties and structural quality of cortical bone, in agreement with the human fracture data, although some aspects of the response to obesity appear to differ by age. Introduction: The association of obesity with bone is complex and varies with age. Diabetic obese adolescents and adult humans have increased fracture risk. Prior studies have shown reduced mechanical properties as a result of high-fat diet (HFD) but do not fully address size-independent mechanical properties or structural quality, which are important to understand material behavior. Methods: Cortical bone from femurs and tibiae from two age groups of C57BL/6 mice fed either HFD or low-fat diet (LFD) were evaluated for structural and bone turnover changes (SEM and histomorphometry) and tested for bending strength, bending stiffness, and fracture toughness. Leptin, IGF-I, and non-enzymatic glycation measurements were also collected. Results: In both young and adult mice fed on HFD, femoral strength, stiffness, and toughness are all dramatically lower than controls. Inferior lamellar and osteocyte alignment also point to reduced structural quality in both age groups. Bone size was largely unaffected by HFD, although there was a shift from increasing bone size in obese adolescents to decreasing in adults. IGF-I levels were lower in young obese mice only. Conclusions: While the response to obesity of murine cortical bone mass, bone formation, and hormonal changes appear to differ by age, the bone mechanical properties for young and adult groups are similar. In agreement with human fracture trends, adult mice may be similarly susceptible to bone fracture to the young group, although cortical bone in the two age groups responds to diabetic obesity differently. © 2010 The Author(s).
Databáze: OpenAIRE
Externí odkaz: