Physical Exercise and Liver Autophagy: Potential Roles of IL-6 and Irisin

Autor: Ana P, Pinto, Eduardo R, Ropelle, Joe, Quadrilatero, Adelino S R, da Silva
Rok vydání: 2021
Předmět:
Zdroj: Exercise and Sport Sciences Reviews. 50:89-96
ISSN: 1538-3008
0091-6331
DOI: 10.1249/jes.0000000000000278
Popis: Autophagic dysregulation contributes to liver diseases. Although some investigations have examined the effects of endurance and resistance exercise on autophagy activation, potential myokines responsible for skeletal muscle-liver crosstalk are still unknown. Based on experimental studies and bioinformatics, we hypothesized that interleukin 6 (IL-6) and irisin might be key players in the contraction-induced release of molecules that regulate liver autophagic responses.
Databáze: OpenAIRE