Impaired nitrergic relaxation in pyloric sphincter of the 6-OHDA Parkinson’s disease rat
Autor: | Yan-Yan Fan, Yue Zhang, Rui-Fang Fan, Tao Wang, Xiao Yu, Li-Fei Zheng, Jin-Xia Zhu |
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Rok vydání: | 2022 |
Předmět: | |
Zdroj: | American Journal of Physiology-Gastrointestinal and Liver Physiology. 322:G553-G560 |
ISSN: | 1522-1547 0193-1857 |
DOI: | 10.1152/ajpgi.00363.2021 |
Popis: | Patients with Parkinson's disease (PD) often suffer from delayed gastric emptying, but the underlying mechanism remains unclear. We have shown previously that a PD rat model comprising bilateral substantia nigra destruction by 6-hydroxydopamine (6-OHDA rats) exhibits gastroparesis with alteration of neural nitric oxide synthase (nNOS) and acetylcholine in gastric corpus. However, changes in pyloric motility in the 6-OHDA rats have not been characterized. Solid gastric emptying test, immunofluorescence, Western blot, and in vitro pyloric motility recordings were used to assess pyloric motor function in the 6-OHDA rats. The 6-OHDA-treated rats displayed delayed solid gastric emptying and a lower basal pyloric motility index. In the 6-OHDA rats, high K |
Databáze: | OpenAIRE |
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