Impaired nitrergic relaxation in pyloric sphincter of the 6-OHDA Parkinson’s disease rat

Autor:	Yan-Yan Fan, Yue Zhang, Rui-Fang Fan, Tao Wang, Xiao Yu, Li-Fei Zheng, Jin-Xia Zhu
Rok vydání:	2022
Předmět:	Gastroparesis Hepatology Physiology Gastroenterology Parkinson Disease Nitric Oxide Synthase Type I Rats Rats Sprague-Dawley nervous system Physiology (medical) Animals Humans Oxidopamine Pylorus
Zdroj:	American Journal of Physiology-Gastrointestinal and Liver Physiology. 322:G553-G560
ISSN:	1522-1547 0193-1857
DOI:	10.1152/ajpgi.00363.2021
Popis:	Patients with Parkinson's disease (PD) often suffer from delayed gastric emptying, but the underlying mechanism remains unclear. We have shown previously that a PD rat model comprising bilateral substantia nigra destruction by 6-hydroxydopamine (6-OHDA rats) exhibits gastroparesis with alteration of neural nitric oxide synthase (nNOS) and acetylcholine in gastric corpus. However, changes in pyloric motility in the 6-OHDA rats have not been characterized. Solid gastric emptying test, immunofluorescence, Western blot, and in vitro pyloric motility recordings were used to assess pyloric motor function in the 6-OHDA rats. The 6-OHDA-treated rats displayed delayed solid gastric emptying and a lower basal pyloric motility index. In the 6-OHDA rats, high K
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965fcf347897be984309bf4d654fb2af https://doi.org/10.1152/ajpgi.00363.2021 Zobrazit plný text záznamu