Probiotics Can Cure Oral Aphthous-Like Ulcers in Inflammatory Bowel Disease Patients: A Review of the Literature and a Working Hypothesis
| Autor: | Dario Saguto, Federica Canepa, Giuseppina Campisi, Giuseppe Bonaventura, Francesca Rappa, Giovanna Giuliana, Alberto Fucarino, Angelo Leone, Federica Scalia, Margherita Mazzola, Francesco Cappello, Fabio Bucchieri, Francesco Carini, Giovanni Tomasello |
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| Přispěvatelé: | Cappello F., Rappa F., Canepa F., Carini F., Mazzola M., Tomasello G., Bonaventura G., Giuliana G., Leone A., Saguto D., Scalia F., Bucchieri F., Fucarino A., Campisi G. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Inflammation Review Working hypothesis Inflammatory bowel disease inflammatory bowel diseases Catalysis Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences 0302 clinical medicine inflammatory bowel disease medicine microbiota aphthous-like ulcers Animals Humans Physical and Theoretical Chemistry Oral mucosa Molecular Biology Stomatitis lcsh:QH301-705.5 Spectroscopy Natural course business.industry dysbiosi Organic Chemistry Inflammatory Bowel Diseases General Medicine dysbiosis medicine.disease muco-microbiotic layer digestive system diseases Computer Science Applications Gastrointestinal Microbiome Disease Models Animal stomatognathic diseases 030104 developmental biology medicine.anatomical_structure probiotics lcsh:Biology (General) lcsh:QD1-999 030220 oncology & carcinogenesis Immunology Stomatitis Aphthous medicine.symptom business Dysbiosis aphthous-like ulcer |
| Zdroj: | International Journal of Molecular Sciences, Vol 20, Iss 20, p 5026 (2019) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | Dysbiosis has been associated with the onset of several chronic autoimmune or inflammatory pathologies (e.g., inflammatory bowel diseases—IBD), because of its primary role in the establishment of a chronic inflammatory process leading to tissue damage. Inflammatory bowel diseases can even involve areas far away from the gut, such as the extraintestinal manifestations involving the oral cavity with the onset of aphthous-like ulcers (ALU). Studies carried out on animal models have shown that intestinal dysbiosis may be related to the development of autoimmune diseases, even if the mechanisms involved are not yet well known. The aim of this paper is to verify the hypothesis that in inflammatory bowel diseases patients, aphthous-like ulcers are the result of the concomitance of intestinal dysbiosis and other events, e.g., the microtraumas, occurring in the oral mucosa, and that ex adiuvantibus therapy with probiotics can be employed to modify the natural course of the aphthous-like ulcers. |
| Databáze: | OpenAIRE |
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