Dosimetric comparison between volumetric modulated arc therapy planning techniques for prostate cancer in the presence of intrafractional organ deformation
| Autor: | Keisuke Otani, Michio Oda, Fumiaki Isohashi, Keita Kurosu, Iori Sumida, Yuji Seo, Kazuhiko Ogawa, Maria Varnava |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Organs at Risk treatment planning Dose-volume histogram Health Toxicology and Mutagenesis Planning target volume Rectum computer.software_genre 030218 nuclear medicine & medical imaging volumetric modulated arc therapy 03 medical and health sciences Prostate cancer 0302 clinical medicine Voxel Regular Paper medicine intrafractional organ deformation Humans Dosimetry Radiology Nuclear Medicine and imaging Radiation treatment planning blurred dose distribution Radiation business.industry Radiotherapy Planning Computer-Assisted Prostatic Neoplasms Radiotherapy Dosage prostate cancer medicine.disease Volumetric modulated arc therapy medicine.anatomical_structure 030220 oncology & carcinogenesis AcademicSubjects/SCI00960 AcademicSubjects/MED00870 Radiotherapy Intensity-Modulated dose–volume histogram Nuclear medicine business computer |
| Zdroj: | Journal of Radiation Research |
| ISSN: | 1349-9157 0449-3060 |
| DOI: | 10.1093/jrr/rraa123 |
| Popis: | The purpose of this study was to compare single-arc (SA) and double-arc (DA) treatment plans, which are planning techniques often used in prostate cancer volumetric modulated arc therapy (VMAT), in the presence of intrafractional deformation (ID) to determine which technique is superior in terms of target dose coverage and sparing of the organs at risk (OARs). SA and DA plans were created for 27 patients with localized prostate cancer. ID was introduced to the clinical target volume (CTV), rectum and bladder to obtain blurred dose distributions using an in-house software. ID was based on the motion probability function of each structure voxel and the intrafractional motion of the respective organs. From the resultant blurred dose distributions of SA and DA plans, various parameters, including the tumor control probability, normal tissue complication probability, homogeneity index, conformity index, modulation complexity score for VMAT, dose–volume indices and monitor units (MUs), were evaluated to compare the two techniques. Statistical analysis showed that most CTV and rectum parameters were significantly larger for SA plans than for DA plans (P |
| Databáze: | OpenAIRE |
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