Dosimetric comparison between volumetric modulated arc therapy planning techniques for prostate cancer in the presence of intrafractional organ deformation

Autor: Keisuke Otani, Michio Oda, Fumiaki Isohashi, Keita Kurosu, Iori Sumida, Yuji Seo, Kazuhiko Ogawa, Maria Varnava
Rok vydání: 2020
Předmět:
Male
Organs at Risk
treatment planning
Dose-volume histogram
Health
Toxicology and Mutagenesis
Planning target volume
Rectum
computer.software_genre
030218 nuclear medicine & medical imaging
volumetric modulated arc therapy
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Voxel
Regular Paper
medicine
intrafractional organ deformation
Humans
Dosimetry
Radiology
Nuclear Medicine and imaging
Radiation treatment planning
blurred dose distribution
Radiation
business.industry
Radiotherapy Planning
Computer-Assisted
Prostatic Neoplasms
Radiotherapy Dosage
prostate cancer
medicine.disease
Volumetric modulated arc therapy
medicine.anatomical_structure
030220 oncology & carcinogenesis
AcademicSubjects/SCI00960
AcademicSubjects/MED00870
Radiotherapy
Intensity-Modulated
dose–volume histogram
Nuclear medicine
business
computer
Zdroj: Journal of Radiation Research
ISSN: 1349-9157
0449-3060
DOI: 10.1093/jrr/rraa123
Popis: The purpose of this study was to compare single-arc (SA) and double-arc (DA) treatment plans, which are planning techniques often used in prostate cancer volumetric modulated arc therapy (VMAT), in the presence of intrafractional deformation (ID) to determine which technique is superior in terms of target dose coverage and sparing of the organs at risk (OARs). SA and DA plans were created for 27 patients with localized prostate cancer. ID was introduced to the clinical target volume (CTV), rectum and bladder to obtain blurred dose distributions using an in-house software. ID was based on the motion probability function of each structure voxel and the intrafractional motion of the respective organs. From the resultant blurred dose distributions of SA and DA plans, various parameters, including the tumor control probability, normal tissue complication probability, homogeneity index, conformity index, modulation complexity score for VMAT, dose–volume indices and monitor units (MUs), were evaluated to compare the two techniques. Statistical analysis showed that most CTV and rectum parameters were significantly larger for SA plans than for DA plans (P
Databáze: OpenAIRE
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