Fibroblast Activation Protein Inhibitor Imaging and Therapy in a Patient With Multiple Endocrine Neoplasia Type 2A Syndrome

Autor:	Somaye, Barashki, Ghasemali, Divband, Emran, Askari, Hamidreza, Amini, Kamran, Aryana
Rok vydání:	2022
Předmět:	Iodine Radioisotopes Positron Emission Tomography Computed Tomography Humans Multiple Endocrine Neoplasia Type 2a Radiology Nuclear Medicine and imaging General Medicine Fibroblasts
Zdroj:	Clinical Nuclear Medicine. 47:e284-e286
ISSN:	1536-0229 0363-9762
DOI:	10.1097/rlu.0000000000004051
Popis:	A patient with multiple endocrine neoplasia type 2A syndrome who had exhausted several surgeries and radiotherapy was referred to nuclear medicine department for theranostic approaches. [68Ga]-DOTATATE PET/CT and [131I]I-mIBG SPECT/CT were performed, but the degree of uptake was insufficient for using the treatment companion of these tracers. Finally, 1 year later, [68Ga]-FAPI-46 PET/CT showed progressive disease with metastases to the lung, liver, bone, and lymph nodes with intense [68Ga]-FAPI-46 uptake. Treatment with [177Lu]Lu-FAPI-46 was done, and the patient tolerated treatment and showed evidence of clinical improvement following therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d656a1f79d2680526a78f16d9f9b26f https://doi.org/10.1097/rlu.0000000000004051 Zobrazit plný text záznamu