Dinitropyrene-resistant Salmonella typhimurium are deficient in an acetyl-CoA acetyltransferase

Autor: Joan C. Orr, D. W. Bryant, D.R. McCalla, Michael A. Quilliam
Rok vydání: 1985
Předmět:
Zdroj: Chemico-Biological Interactions. 54:281-288
ISSN: 0009-2797
DOI: 10.1016/s0009-2797(85)80169-1
Popis: Summary Salmonella typhimurium strain TA98NR which is sensitive to 1,8-dinitropyrene mutagenesis possesses acetyl-CoA dependent acetyltransferase activity, while a strain selected for resistance to 1,8-dinitropyrene (TA98/1, 8-DNP6) is deficient in this activity. Acetyltransferase competent strains can acetylate 1,8-diaminopyrene, forming 1-N-acetylamino-8-aminopyrene and 1,8-N,N′-diacetyldiaminopyrene. The coincidence of dinitropyrene resistance and acetyltransferase deficiency implicates acetylation as an important process in the metabolic activation of dinitropyrene to a mutagenic intermediate.
Databáze: OpenAIRE