Dinitropyrene-resistant Salmonella typhimurium are deficient in an acetyl-CoA acetyltransferase
| Autor: | Joan C. Orr, D. W. Bryant, D.R. McCalla, Michael A. Quilliam |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Salmonella typhimurium
Salmonella Pyrenes Chemistry Mutagenesis Drug Resistance Microbial Mutagen General Medicine Toxicology medicine.disease_cause Ames test Nitroreductase Biochemistry Acetyl Coenzyme A Acetyltransferases Acetylation Acetyltransferase Mutation medicine NAD+ kinase Acetyl-CoA C-Acetyltransferase Biotransformation Chromatography High Pressure Liquid Mutagens |
| Zdroj: | Chemico-Biological Interactions. 54:281-288 |
| ISSN: | 0009-2797 |
| DOI: | 10.1016/s0009-2797(85)80169-1 |
| Popis: | Summary Salmonella typhimurium strain TA98NR which is sensitive to 1,8-dinitropyrene mutagenesis possesses acetyl-CoA dependent acetyltransferase activity, while a strain selected for resistance to 1,8-dinitropyrene (TA98/1, 8-DNP6) is deficient in this activity. Acetyltransferase competent strains can acetylate 1,8-diaminopyrene, forming 1-N-acetylamino-8-aminopyrene and 1,8-N,N′-diacetyldiaminopyrene. The coincidence of dinitropyrene resistance and acetyltransferase deficiency implicates acetylation as an important process in the metabolic activation of dinitropyrene to a mutagenic intermediate. |
| Databáze: | OpenAIRE |
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