Treatment outcomes of Nigerian patients with tuberculosis: A retrospective 25-year review in a regional medical center
| Autor: | Stacene R. Maroushek, Yiong Huak Chan, Tina M. Slusher, Daniel A. Gbadero, Michael Abel Alao, Adanze Onyenonachi Asinobi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Bacterial Diseases
RNA viruses Male Pediatrics Physiology Economics Treatment outcome Human immunodeficiency virus (HIV) Antitubercular Agents Social Sciences HIV Infections Economic Geography medicine.disease_cause Pathology and Laboratory Medicine Geographical Locations Tertiary Care Centers 0302 clinical medicine Continuous evaluation Medical Conditions Immunodeficiency Viruses Risk Factors Global health Medicine and Health Sciences Public and Occupational Health 030212 general & internal medicine Child Aged 80 and over Multidisciplinary Geography Middle Aged Socioeconomic Aspects of Health Body Fluids Actinobacteria Infectious Diseases Treatment Outcome Medical Microbiology Viral Pathogens Child Preschool Viruses Medicine Tuberculosis Diagnosis and Management Low and Middle Income Countries Female medicine.symptom Pathogens Anatomy 0305 other medical science Research Article Adult medicine.medical_specialty Tuberculosis Adolescent Science MEDLINE Nigeria Microbiology 03 medical and health sciences Young Adult Diagnostic Medicine Retroviruses medicine Humans Microbial Pathogens Directly Observed Therapy Aged Retrospective Studies 030505 public health Bacteria business.industry Lentivirus Organisms Sputum Infant Newborn Biology and Life Sciences HIV Infant medicine.disease Tropical Diseases Health Care Treatment Adherence and Compliance Mucus People and Places Africa Earth Sciences business Mycobacterium Tuberculosis |
| Zdroj: | PLoS ONE PLoS ONE, Vol 15, Iss 10, p e0239225 (2020) |
| ISSN: | 1932-6203 |
| Popis: | IntroductionTuberculosis (TB) remains a global health challenge and leading infectious killer worldwide. The need for continuous evaluation of TB treatment outcomes becomes more imperative in the midst of a global economic meltdown substantially impacting resource-limited-settings.MethodsThis study retrospectively reviewed 25-years of treatment outcomes in 3,384 patients who were managed for TB at a tertiary hospital in Nigeria. Confirmed TB cases were given directly observed therapy of a short-course treatment regimen and monitored for clinical response.ResultsOut of 1,146,560 patients screened, there were 24,330 (2.1%) presumptive and 3,384 (13.9%) confirmed TB cases. The patients' mean age was 35.8 years (0.33-101 years). There were 1,902 (56.2%) male, 332(9.8%) pediatric, and 2,878 (85%) pulmonary TB cases. The annual mean measured treatment outcomes were as follows: adherence, 91.4(±5.8) %; successful outcome, 75.3(±8.8) % potentially unsatisfactory outcome, 14.8(±7.2) %; and mortality 10.0(±3.6) %. Female, extra-pulmonary TB (EPTB), newly diagnosed, and relapsed patients compliant with treatment had successful outcomes. Adulthood and HIV infection were mortality risk factors.ConclusionThe mean annual successful treatment outcome is 75.3(±8.8) %. Female, pediatric, EPTB, new, and relapsed patients were predisposed to successful treatment outcomes. Lessons learned will guide future program modifications. |
| Databáze: | OpenAIRE |
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